Typically when you get this message in SAP PI, it means that the system you are trying to send a message to is not setup to receive the message. The way to correct this error is to go on the receiver system an set the Integration Engine Configuration in transaction SXMB_ADM.
Go to Edit >> Change Global Configuration Data.
Role of Business System: Application System
Corresponding Integ. Server: dest://[Integration Server RFC destination]
Save and retry.
Keep in mind that if you are doing this with messages from SRM to SUS (and SUS is a separate client on your SRM system) you will need to configure this in both clients.
Hope this helps...
